Nutritional Supplements Library
What is Arachidonic Acid ?
Arachidonic acid (AA) is an Omega-6 essential fatty acid. It is stored in cell membranes, and is responsible for signaling adaptive changes in response to muscle damage or other stimuli. The arachidonic acid supplementation protocols for stimulating muscle growth were developed and patented by performance-enhancement scientist William Llewellyn (1).
What is the effective dosage of Arachidonic Acid Supplementation?
The optimal dosage may vary with each individual and their particular goals. Use typically ranges from 75mg-250mg per day for long-term supplementation and anabolic support, to as much as 500mg-1000mg per day for a more rapid anabolic effect. During use some people notice increased muscle soreness, sore joints, headaches, or insomnia. Most users do not notice any significant side effects.
What are the benefits of Arachidonic Acid supplementation?
• Reduced Arachidonic acid levels are associated with "training stagnation", or a declining ability to stimulate muscle growth, strength gains, and delayed-onset muscle soreness (DOMS) following exercise.
• Arachidonic acid is the principle building block for the synthesis of dienolic prostaglandins including PGE2 and PGF2. These prostaglandins are intimately involved with protein synthesis and muscle hypertrophy after exercise. Arachidonic acid is specifically correlated with amplified IGF-1 (Insulin-Like Growth Factor) signaling , enhanced satellite cell activation and proliferation , increased muscle cell regeneration and repair , enhanced androgen receptor synthesis , increased Nitric Oxide formation , and improved insulin sensitivity.
What are the side effects of Arachidonic Acid supplementation?
Arachidonic acid is a natural and important essential fatty acid (EFA), and is safe for healthy people to take. The supplementation of doses as high as 1,500-1,700mg per day should not cause a change in HDL, LDL, or total cholesterol values, immune system functioning, or platelet aggregation values. Furthermore, it is safe on all of the basic markers of health including lipids, blood pressure, blood cell counts, immune system mediators, and liver enzymes.
Sedentary (inactive) individuals should not supplement with AA unless a dietary need has been identified, as deficiency in this group is not common. AA supplementation is also not recommended during pregnancy, or by individuals with a history of diabetes, asthma, high blood pressure, high cholesterol, arthritis, heart disease, stroke, colitis, irritable bowel syndrome, cancer, prostate enlargement, or any inflammatory disease.