Nutritional Supplements Library
What is L-carnitine?
L-carnitine is derived from the lysine and methionie amino acids. It is mainly synthesized in the liver and the kidneys, and must be transported for use to other tissues in the body. It sometimes mistakenly referred as an amino acid but chemically it is classified as aquaternaryamine. It is found in highest concentration in tissues that use fatty acids as the main dietary fuel, such as the skeletal and cardiac muscles. It is present in many of the foods we eat, such as meats, vegetables, and grains. For example, beef has about 145mg of l-carnitine per every 100 grams, compared to only 2.6mg per every 100grams of mushroom. It's even less for other vegetables such as carrots with only 0.4mg. Obviously, if you're a vegetarian, you're at a disadvantage for carnitine sources compared to someone who eats meat in their regular diet.
What are the effective dosages of L- Carnitine supplement?
For nutritional purpose 250 to 500mg every day is useful. Higher dosages than this should be used under doctor's supervision.
What are the benefits of L- Carnitine supplement?
• The heart is completely dependant upon carnitine; two third of its energy supply comes from the fats that carnitine allows the body to burn. After heart attack ,several complication are likely ,including chest pains,heart rhythm disturbance and heart failure.taking 2 grams of l-carnitine per day for four weeks ,hospital based studies show,can cut the numbers of those complications in half.
• One of the primary benefits of L- carnitine supplement is weight loss because it transports the fatty acids into the cells mitochondria,where energy is produced.
• It is very beneficial for endurance athletes because it provides fatty acids to heart muscle for energy, two third of heart's energy supply comes from the fats that L-carnitine allows the body to burn.
• By adding acetyl molecule to L- carnitine ,the new molecule acetyl-L- carnitine has enhanced activity (cellular energy) in brain, is reported to be associated with the formation of the neurotransmitter acetylcholine. Acetyl-L-carnitine contributes to the production of the neurotransmitter acetylcholine, a compound that is believed to improve mental function.
• It has been suggested that acetyl-L-carnitine may play a part in delaying the progression of Alzheimer's disease and enhance performance in some Alzheimer's patients.
• Acetyl-L-Carnitine may have certain anti-aging properties.
• Some scientists claim that acetyl-L-carnitine may be a helpful supplement for people with degenerative cerebellar ataxia, a loss of muscular coordination caused by disease in the cerebellum.
What are the side effects of L- Carnitine?
L- Carnitine supplements have a good safety record with no major adverse side effects. There are very few documented side effects, and they include, Increase in blood pressure, Faster heartbeats Fever ,Large amounts may cause diarrhea.L- carnitine is safe supplement at moderate dosages.
Cautions - because Acetyl-carnitine enhance the brain activity, avoid taking it after dinner, it may interfere with sleep. People with epilepsy should use it extreme cautions because their brains already are overly sensitive to neutral stimulation.
What is L-carnitine deficiency?
In certain conditions, the demand for carnitine may exceed a person's ability to synthesize it, thus making it a conditionally essential nutrient. As said above, individuals who eat little to no meats (vegetarians) will benefit from supplementation of L-Carnitine. Although deficiencies are uncommon, muscle fatigue, cramping are some signs of possible deficiency.
Generally, deficiency is categorized as primary and secondary carnitine deficiencies.
Primary Carnitine Deficiency
These are relatively rare hereditary disorders, such as:1)Systemic deficiency 2)Myopathic deficiency . These deficiencies are generally characterized by low carnitine levels, poor absorption of l-carnitine from diet, muscle pain, progressive muscle weakness, etc. The myopathic deficiency is less severe than the systemic form.
Secondary L Carnitine Deficiency
This form can be hereditary, or acquired, and generally, there's is low levels of available l-carnitine. This can be characterized by:1)Increased loss of carnitine 2)Insufficient synthesis of carnitine 3)Malabsorption from diet These forms of deficiency are generally rare, and although vegetable sources contain much less (close to none) L-Carnitine, vegetarians can usually synthesize enough carnitine to prevent deficiency. However, among pre-mature infants, children, and breast-feeding women, vegetarians are more likely to be deficient.