Mayur Deshpande
  Personal trainer in Mumbai
Nutritional Supplements Library Pregnenolone

Nutritional Supplements Library

Pregnenolone


What is Pregnenolone??

Pregnenolone is a steroid hormone that is manufactured from cholesterol by cellular mitochondria. It is made by the body. It serves as a precursor to other hormones, including dehydroepiandrosterone (DHEA) and progesterone. Pregnenolone is made in many organs and tissues that produce steroid hormones. The most common of these organs are the adrenal glands, liver, skin, and gonads (testicles and ovaries).There are enzymes in cells that convert cholesterol to Pregnenolone. Each of the tissues and organs in our body has a different activity of this enzyme and thus it is made in varying amounts in different parts of our body. The parts of the cell where it is made are called mitochondria. Mitochondria are the chemical factories of a cell.


What is the effective dosage of pregnenolone supplementation?

Clinical studies have used pregnenolone in dosages of 25 to 100 mg per day. It is for short term use only, one to three months. The effect becomes more pronounced in late afternoon and evening. You should be patient with Pregnenolone since, if you're taking a low dose, it sometimes takes up to two weeks or a month to notice the effects.

What are the benefits of pregnenolone supplementation?

• Pregnenolone is useful to maintain a healthy immune system and maintain healthy stress levels.
• It helps to develop memory.
• It alleviates stress; it lowers the stress hormones if they are inappropriately elevated.
• Provides a mild, calm, pleasant feeling.
• In late 1940, it was famous for treating arthritis.


What are the side effects of pregnenolone supplementation?

They are no known side effects associated with pregnenolone in moderate dosage. But we're still in the early stages of learning about pregnenolone and its full effects on the human body. It is best to proceed with caution until more information is available. This means using the lowest effective dose and seeking supervision by a knowledgeable health care provider. Discontinue the use if you experienced any adverse side effects and consult your doctor.
Cautions-
• Do not use pregnenolone if you are supplementing DHEA.Do not use if you suffer from seizure disorders, as pregnenolone can suppress GABA activity, resulting in an increase in central nervous system activity which may lead to seizures in those with epilepsy. Clinical research using pregnenolone supplements is limited.
Pregnenolone can be converted into DHEA which in turn is converted into androgens, estrogens and other steroids.But there's another pathway that Pregnenolone can take. It can be metabolized into progesterone which in turn can turn into aldosterone or corti-sol.
In a laboratory, Diosgenin(wild yam) is converted into Pregnenolone but The human body does not have the ability (the required enzymes) to convert Diosgenin into Pregnenolone. Because of the lack of standardization of the products that are available, people should be very cautious, and to use it only if there is a clear reason to do so. Always start with small dosage.


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