Nutritional Supplements Library
What is Tyramine ?
Tyramine (4-Hydroxyphenethylamine; para-Tyramine; Mydrial, Uteramin) is a naturally-occurring monoamine compound and trace amine derived from the amino acid tyrosine. When ingested unintentionally from certain foods in conjunction with a monoamine oxidase inhibitor (MAOI), tyramine is responsible for the so-called "cheese effect" often seen with their use. It acts as a neurotransmitter.Food sources for Tyramine include red wine, bean curd, fava beans, cheeses, sausage, bologna, pepperoni, figs, raisins, avocados, green bean pods, eggplant, pickled herring, canned meats, yogurt, soup cubes, chocolate and soy sauce.
What is the effective dosage of Tyramine supplementation?
For those who choose to use Tyramine, a dose of 200 mg is recommended, as this is enough to significantly increase plasma levels, but is well within the safety range. As with any new stimulant, the starting dose should be very low and increased as tolerated.
What are the benefits of Tyramine supplementation?
• Tyramine helps to induce fat loss by increasing adrenalin secretion, by increasing muscular glucose uptake in the absence of simple carbohydrates, thus eliminating or reducing the need for rises in insulin levels.
• For the dieting athlete, Tyramines ability to increase glucose uptake in the absence of simple carbohydrate means that insulin spikes can be avoided and muscle glycogen stores can be restored post-exercise.
• Elevated insulin levels can lead to decreases in growth hormone, IGF-1 and testosterone levels. Within the context of high body fat percentages, elevated insulin levels will lead to a decrease in protein synthesis, and an increase in muscular atrophy. Not good. Dieting athletes know that controlling insulin is key to becoming and staying lean.
• Tyramine affects blood pressure, although clinical research demonstrates that its effects upon blood pressure are mixed. Any effects of tyramine on blood pressure is believed to result from tyramines conversion into octopamine and synephrine.
What are the side effects of Tyramine supplementation?
• Tyramine-containing foods interact with drug class: Monoamine Oxidase Inhibitors.
• May increase blood pressure and heart rate, especially in higher amounts.
• Some people report unusual sensitivity to dietary tyramine. Although the scientific evidence does not presently support a link between dietary tyramine and adverse reactions in those who are not taking an MAOI, idiosyncratic reactions are always a possibility. For this reason, anyone choosing to take supplemental tyramine should start with a low dose to guage their reaction.
Because there is little human research, tyramine does not have a well-established side effect profile.